Suchergebnisse

Vorliegende Diplomarbeit befasst sich mit Ansätzen, Strategien und Perspektiven aus diversen Fachdisziplinen und Arbeitsbereichen, die zur nachhaltigen Stadtentwicklung und Freiraumgestaltung beitragen können. Dabei werden mit literaturanalytischen Methoden Aspekte aus Stadt- und Verkehrsplanung, Städtebau, Architektur, Ökologie, Sozioökonomie, Politik, Philosophie und Permakultur aus der Perspektive von Freiraumgestaltung und Landschaftsarchitektur dargestellt und analysiert, wobei ein direkter, spezifischer Bezug zur Stadtregion Wien hergestellt wird. Weiters werden urbane Utopien, theoretische Methoden sowie ausgewählte aktuelle Beispiele in diesen Kontext gestellt. Die Ergebnisse werden folglich über den Diskurs der Literatur zusammenfassend und vergleichend analysiert und in einem allgemeinen, umfassenden und breit gefächerten Bild einer möglichen "grünen Stadt der Zukunft" zusammengeführt, integriert und diskutiert. Die dabei erarbeiteten allgemeinen Anwendungsstrategien einer nachhaltigen Stadtentwicklung und Freiraumgestaltung umfassen unter anderem die Nutzung synergistischer Effekte zwischen Stadt und Umland beispielsweise mittels postindustrieller Nachnutzung durch Regionalparks, die Förderung einer polyzentrischen, kompakten Stadtstruktur und kleinteiliger, funktions- und nutzungsdurchmischter Stadtquartiere im Sinne einer "Stadt der kurzen Wege" mit geringer Mobilität und hoher Durchlässigkeit der Freiräume, die Nutzung des ökologischen, ökonomischen sowie sozialen Potentials von öffentlichen sowie privaten städtischen Grün- und Freiräumen durch "Urban Gardening" und urbane Permakultur sowie die Förderung des ökologischen Bauens mittels Dach-, Fassaden- und Innenhofbegrünung. Folglich sollen die erarbeiteten Anwendungsstrategien auch zum allgemeinen Diskurs einer nachhaltigen Stadtentwicklung und Freiraumgestaltung sowie zu deren speziellen Diskussion und Anwendung im Kontext der Stadtregion Wien beitragen. ; This diploma thesis deals with approaches, strategies and perspectives from various disciplines and fields which can contribute to sustainable urban development and open space design. On the basis of literature analytic methods aspects of town and transport planning, urban design, architecture, ecology, socio-economics, politics, philosophy and permaculture from the perspective of open space design and landscape architecture are presented and analyzed, with a direct, specific reference to the urban region of Vienna is produced. Further urban utopias, theoretical methods and selected recent examples are provided. Therefore, by the discourse of literature the results are summarized, compared and analyzed and a general, extensive and broadly diversified picture of a possible "green city of the future" is integrated, outlined and discussed. The developed general application strategies for sustainable urban development and design of open space include, among other things, the use of synergistic effects between the city and surrounding areas for example by means of post-industrial re-use of regional parks, the promotion of a polycentric, compact urban structure and small-scale, functionally mixed neighbourhoods in terms of a "city of short ways" with low mobility and high permeability of open space, the use of ecological, economic and social potential of public and private urban green and open spaces through "Urban Gardening" and urban permaculture and the promotion of ecological construction through the greening of roofs, facades and courtyards. Consequently, the developed application strategies should also contribute to the general discourse of sustainable urban development and open space design as well as to a specific discussion and application in the context of the urban region of Vienna. ; eingereicht von: Martin Konrad Zopf ; Zsfassung in engl. Sprache ; Wien, Univ. für Bodenkultur, Dipl.-Arb., 2012 ; (VLID)1127546

Hereditary cystic kidney diseases comprise a complex group of genetic disorders representing one of the most common causes of end-stage renal failure in childhood. The main representatives are autosomal recessive polycystic kidney disease, nephronophthisis, Bardet–Biedl syndrome, and hepatocyte nuclear factor-1beta nephropathy. Within the last years, genetic efforts have brought tremendous progress for the molecular understanding of hereditary cystic kidney diseases identifying more than 70 genes. Yet, genetic heterogeneity, phenotypic variability, a lack of reliable genotype–phenotype correlations and the absence of disease-specific biomarkers remain major challenges for physicians treating children with cystic kidney diseases. To tackle these challenges comprehensive scientific approaches are urgently needed that match the ongoing "revolution" in genetics and molecular biology with an improved efficacy of clinical data collection. Network for early onset cystic kidney diseases (NEOCYST) is a multidisciplinary, multicenter collaborative combining a detailed collection of clinical data with translational scientific approaches addressing the genetic, molecular, and functional background of hereditary cystic kidney diseases. Consisting of seven work packages, including an international registry as well as a biobank, NEOCYST is not only dedicated to current scientific questions, but also provides a platform for longitudinal clinical surveillance and provides precious sources for high-quality research projects and future clinical trials. Funded by the German Federal Government, the NEOCYST collaborative started in February 2016. Here, we would like to introduce the rationale, design, and objectives of the network followed by a short overview on the current state of progress.

Hereditary cystic kidney diseases comprise a complex group of genetic disorders representing one of the most common causes of end-stage renal failure in childhood. The main representatives are autosomal recessive polycystic kidney disease, nephronophthisis, Bardet–Biedl syndrome, and hepatocyte nuclear factor-1beta nephropathy. Within the last years, genetic efforts have brought tremendous progress for the molecular understanding of hereditary cystic kidney diseases identifying more than 70 genes. Yet, genetic heterogeneity, phenotypic variability, a lack of reliable genotype–phenotype correlations and the absence of disease-specific biomarkers remain major challenges for physicians treating children with cystic kidney diseases. To tackle these challenges comprehensive scientific approaches are urgently needed that match the ongoing "revolution" in genetics and molecular biology with an improved efficacy of clinical data collection. Network for early onset cystic kidney diseases (NEOCYST) is a multidisciplinary, multicenter collaborative combining a detailed collection of clinical data with translational scientific approaches addressing the genetic, molecular, and functional background of hereditary cystic kidney diseases. Consisting of seven work packages, including an international registry as well as a biobank, NEOCYST is not only dedicated to current scientific questions, but also provides a platform for longitudinal clinical surveillance and provides precious sources for high-quality research projects and future clinical trials. Funded by the German Federal Government, the NEOCYST collaborative started in February 2016. Here, we would like to introduce the rationale, design, and objectives of the network followed by a short overview on the current state of progress.